NK cell expression of Tim-3: First impressions matter
نویسندگان
چکیده
منابع مشابه
Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.
The immunoregulatory protein T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates T-cell exhaustion and contributes to the suppression of immune responses in both viral infections and tumors. Tim-3 blockade reverses the exhausted phenotype of CD4+ and CD8+ T cells in several chronic diseases, including melanoma. Interestingly, natural killer (NK) cells constitutively e...
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Objective(s): As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. Materials and Meth...
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ژورنال
عنوان ژورنال: Immunobiology
سال: 2019
ISSN: 0171-2985
DOI: 10.1016/j.imbio.2019.03.001